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Figure 4


Fig. 4. Ultrastructural defects in third-instar larval Malpighian tubules of npc2a mutants. (A) Wild-type Drosophila melanogaster;(B-D) npc2a mutants. Large multi-lamellar structures (arrows in B and C) and multivesicular bodies (arrow in D) are present in npc2a mutants but not wild-type tubules. The multi-lamellar structures were often clustered together to form large inclusions with or without electron-dense whorls within (arrowhead in C and arrow in B, respectively). M, mitochondria.