Fig. 3. Cortical and ventral patterning is preserved in Bmpr1a;Bmpr1b mutant mice. RNA in situ hybridization on E10.5 coronal sections. (A-D) The domains of expression for Lhx2 (A,B) and Foxg1 (C,D) are unchanged in the mutant and remain excluded from the dorsomedial area (arrowheads in A-D). (E-H) Fgf8 expression is absent from the most anterior region along the rostral midline (E,F), but is maintained ventrally, as seen in more posterior sections (G,H). (I-L) The ventromedial markers Nkx2.1 (I,J) and Gli1 (K,L) are expressed in the mutant, suggesting that ventral cell fate is unaffected and that SHH signaling is active. Scale bars: 275 µm.