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Figure 1


Fig. 1. bro-1 is a CBFß orthologue. (A) Genomic structure of the bro-1 gene and the region contained in the rescuing construct pHK196. (B) Alignment of BRO-1 and CBFß orthologues from Drosophila (Brother, NP477066.2 and Big brother, NP477065.3), mouse (NP071704.2) and human (isoform 1, NP074036.1). Identical amino acids are shown on a black background; similar amino acids are on a grey background. The secondary structure profiles determined for mouse CBFß (open box, {alpha} helix; black box, ß sheet) are shown on the top of the alignment (Tahirov et al., 2001), indicating the RUNX1-interacting regions, and including the particular amino acids that would be expected to participate in the direct interaction.