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Figure 1


Fig. 1. Co-expression of seven Hoxd genes in posterior midgut. (A) Whole-mount RNA in situ hybridization detection of Hoxd10 transcripts in E13 mouse embryo, showing some sites of expression, including the intestinal hernia. (B) Anatomical subdivisions of the mid-gestation murine gastrointestinal system at E12. (C-K) Detection of Hoxd13 (C), Hoxd12 (D), Hoxd11 (E), Hoxd10 (F), Hoxd9 (G), Hoxd8 (H), Hoxd4 (I), Hoxd3 (J) and Hoxd1 (K) transcripts in dissected gut of E12.5 mouse embryos. The contiguous loci Hoxd1 to Hoxd10 are all co-expressed in the posterior midgut, in the region that involves the incipient caecum bud (F-K). Hoxd11 is excluded from the anterior (ileal) part, but is expressed in the posterior (colonic) part of the caecum bud (E). Hoxd12 (D) and Hoxd13 (C) expression is not detected in this region. ce, caecum; co, colon; oes, oesophagus; sb, small bowel; st, stomach.