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Figure 5


Fig. 5. FGF signaling is not sufficient to position the RA-responsive domain in the PSM. (A,B) Cyp26 expression in the posterior region of the Fgfr1f/f;T-Cre (B) mutant is downregulated compared with that in Fgfr1f/+;T-Cre control (A) embryos. (C,D) There is a lack of significant change in RA activity, as detected by crossing to RARE-lacZ reporter mice, in Fgfr1f/f;T-Cre mutant (D) compared with the Fgfr1f/+;T-Cre control (C) embryos. (E,F) Expression of Raldh2 is not significantly changed in the PSM of Fgfr1f/f;T-Cre mutant embryos (F) compared with control Fgfr1f/+;T-Cre (E) embryos.