Fig. 5. Differentiation abnormalities of lateral blastemas in animals with perturbed smedbmp4-1 signaling. (A-D) Diagrams in A and C show the sites of amputation (black lines) that generate thick or thin fragments that lack bilateral symmetry. Animals were examined at 14 days (unc-22 and smedsmad4-1 RNAi animals) and 22 days (smedolloid-1 and smedbmp4-1 RNAi animals) after amputation. White arrows indicate the wounded side. (A,B) Thick fragments. (C,D) Thin fragments. (B,D) Animals were labeled with the D.21.6 riboprobe that recognizes cells at the animal boundary (purple). Anterior, left. Scale bar: 0.1 mm.