Development -- Potthoff and Olson 134 (23): 4131 Figure IG5

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Fig. 5. Control of anterior heart field development by MEF2C. MEF2C expression in the anterior heart field is controlled by GATA4, ISL1 and FOXH1, together with NKX2-5. MEF2C directly activates the expression of BOP, which is required for expression of HAND2, an essential regulator of anterior heart field development. Solid lines indicate direct regulatory interactions and dotted lines indicate regulatory interactions for which the underlying mechanism has not yet been defined.