Development -- Potthoff and Olson 134 (23): 4131 Figure IG6

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Fig. 6. Control of neural crest development by MEF2C. Signaling by endothelin 1 (EDN1) through the ET-A receptor (EDNRA) activates MEF2C expression in the neural crest. MEF2C directly activates the expression of DLX5 and DLX6, which regulate the expression of HAND2. Together, these factors regulate the expression of genes required for craniofacial development.