Fig. 7. Model of the angiopoietin 2-dependent cell death switch. (A) Hyaloid VECs will survive when Ang1 activates Akt, suppresses cell death and promotes proliferation through β-catenin stabilization. (B) Hyaloid VECs will die when Ang2 promotes cell death via suppression of Akt and cell cycle entry by upregulating Wnt7b in macrophages. In the absence of survival signals the cycling hyaloid VECs will undergo apoptosis in the G1 phase of the cell cycle.