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Figure 6


Fig. 6. RNAi directed against integrin subunits causes similar phenotypes to, and interactions with, perd and Grip. (A-D) High concentrations of dsRNA for the βPS integrin gene mys (B), the {alpha}PS2 gene if (C), or the {alpha}PS1 gene mew (D) cause muscle rounding, particularly in the ventral region. (Compare with negative control dsRNA in A.) (E-I) Pooled data from quadruplicate experiments combining low-concentration dsRNAs shows that mew exhibits synergistic interactions with if (E; P<10-4 by {chi}2 test against predicted additive distribution), perd (F; P<10-6), and Grip (G; P<10-24), whereas if interacts significantly with Grip (I; P<10-20) but not with perd (H).