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Figure 3


Fig. 3. Dysgenesis of the body wall, bladder and GT in Shh null mutants. (A-H) H&E-stained mid-sagittal sections of wild-type (A,B,E,F) and Shh-/- (C,D,G,H) specimens at E13.5 (A-D) and at newborn stages (E-H). Higher magnifications of the GT and bladder primordia (boxed in A,C,E,G) are shown in B,D,F,H. The blue arrows in D and H indicate mutant bladder primordia; the green arrows in E indicate internal (pelvic) urethra. am, abdominal muscle; b, bladder; bs, bladder smooth muscle; bw, body wall; eg, external genitalia; p, pelvic bone; r, rectum; u, internal urethra; uc, umbilical cord.