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Figure 4


Fig. 4. Urogenital tissue defects in Gli mutant mice. (A-C) Mid-sagittal H&E sections of urogenital organs in newborns with genotypes indicated. Urogenital tissue defects present in Gli2-/- embryos (B) were exacerbated in Gli1-/-;Gli2+/- embryos (C) as compared with controls (Gli1-/- or Gli2+/- embryos, data not shown). am, abdominal muscle; b, bladder; eg, external genitalia; p, pelvic bone; r, rectum; u, internal urethra.