Fig. 1. PCP phenotype in the Drosophila eye and wing, and subcellular localization of PCP proteins in wing epithelial cells. (A) A WT eye. (B) Vang mutant eye. The left panels show the arrangement of individual photoreceptor rhabdomeres (the central grey or black circular structures within each ommatidium). The right panels are schematics of the chirality and orientation of each ommatidium (black or red arrows for the different chiralities; green for nonchiral) and of the equator separating the two territories of differing chirality. In the Vang mutant eye, the ommatidia show defects in both chirality and rotation. (C) WT wing showing the nearly parallel alignment of distally pointing wing hairs. (D) Vang mutant wing showing aberrant wing hair orientations globally, but substantial alignment locally. Arrow indicates proximal (P) and distal (D); anterior is up. (E) The subcellular localization of PCP proteins in the Drosophila wing epithelium (Adler, 2002; Strutt, 2002; Klein and Mlodzik, 2005; Strutt and Strutt, 2005). Four adjacent hexagonal wing epithelial cells are shown, with PCP protein accumulation at proximal or distal faces coded in red or green, respectively. A-D reproduced with permission from Jenny and Mlodzik (Jenny and Mlodzik, 2006). Dgo, Diego; Ds, Dachsous; Dsh, Dishevelled; Fz, Frizzled; Pk, Prickle; Vang/Stbm, Van Gogh/Strabismus; Stan/Fmi, Starry night/Flamingo.