Fig. 5. Diminished androgen dependency in Fgfr2^cn prostates with respect to tissue homeostasis. (A) Fgfr2^cn and control mice were orchiectomized to eliminate testisderived androgens. At the indicated day after the operation, the prostate tissues were harvested and apoptotic cells were detected with TUNEL assay. (B) HE staining of the same tissues showing that castration failed to induce tissue atrophy in Fgfr2^cn prostates. F/F, homozygous Fgfr2^flox mice; CN, Fgfr2^cn mice.