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Figure 5


Fig. 5 . Syne-1 and Syne-2 double-knockout mice die soon after birth. (A,B) Newborn Syne DKO mice (B) appeared cyanotic at birth compared to their double-heterozygous littermates (A). (C,D) Longitudinal sections of E18.5 diaphragms. Syne DKO embryo displayed grossly normal muscle anatomy (D) compared to Syne-1+/-; Syne-2+/- (C). (E,F) Postmortem histological analysis of the lung showed that the alveoli air sacs of DKO mice were not expanded (F), indicating the failure of breathing. A Syne-1+/-; Syne-2+/- littermate was used as the control (E). Scale bars: 25 µm in D for C,D; 100 µm in F for E,F.