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Figure 6


Fig. 6 . Nuclear-anchorage defects in muscle of Syne DKO mice. (A-D) Representative NMJs from E18.5 triangularis sterni of the four different Syne-knockout genotypes. Sy1 and Sy2 represent Syne-1 and Syne-2, respectively. Blue, DAPI; red, BTX. Notice that one synaptic nucleus (blue) stayed under the NMJ (red) in A and C, but not in B or D. (E) Statistical data showed that the Syne-1-/-; Syne-2+/- and Syne DKO embryos displayed a significant loss of synaptic nuclei compared with embryos of the other two genotypes. Scale bar: 10 µm.