Fig. 4. Alignment of selected sequences from peptidase family M28. Sequences have been selected from an alignment of all known peptidase members of family M28. Sequences are numbered according to the type example for the family, aminopeptidase S (Streptomyces griseus). Active site residues are indicated by asterisks, and metal ligands by hash (#) symbols. The cysteines involved in the known disulfide bridge in aminopeptidase S are indicated (+). Cysteines taking part in the same disulfide bridge are denoted as/1 and 1\. Key to sequences: (a) aminopeptidase S (Streptomyces griseus); (b) aminopeptidase Ap1 (Vibrio proteolyticus); (c) glutamate carboxypeptidase II (Homo sapiens); (d) agCP10156 protein (Anopheles gambiae); (e) agCG47216 protein (Anopheles gambiae); (f) Fxna peptidase (Rattus norvegicus); (g) Fxna peptidase (Mus musculus); (h) Fxna peptidase (Pan troglodytes); (i) Fxna peptidase (Homo sapiens); (j) Fxna peptidase (Canis familiaris); (k) Fxna peptidase (Gallus gallus); (l) IAP aminopeptidase (Escherichia coli).