Fig. 6. Notch3 mediates Jagged 2 signaling in the pronephros. (A) Expression of notch3 in the pronephros (arrowheads). (B) Expression of notch3 in the proximal pronephric tubules (arrowhead). (C,D) shippo1 expression in single cells of control embryos at 34 hpf (C) is expanded by notch3 exon 27-morpholino injection (D). (E,F) Similarly, expression of flr that is observed in control embryos (E) is expanded in notch3 exon 27 morphants (F). (G,I) Transporting-cell markers slc13a1 (G) and trpM7 (I) are greatly reduced in notch3 exon 27 morphants (H and J, respectively).