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Figure 8


Fig. 8. Schematic depicting the role of Ptf1a in retinal cell development. During retinogenesis, expression of Neurod1 and Neurod4 initiates specification of RPCs to amacrine precursor cells, after which they migrate to the innermost zone of the NBL. Ptf1a induces amacrine cell precursors to differentiate into GABAergic and glycinergic amacrine cells. In addition, Ptf1a is essential in the specification of horizontal precursor cells to horizontal cells.