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Figure 1


Fig. 1. BMP4 is expressed in the ventral mesenchyme during embryonic mammary gland development. (A) ß-galactosidase staining of a Bmp4-lacZneo embryo on E12.5. In these embryos ß-galatosidase is expressed under the control of the BMP4 promoter. At this stage of development, BMP4 is normally prominently expressed on the ventral surface of the embryo. (B) Cross-section of an E13.5 Bmp4-lacZneo mammary bud. BMP4 is expressed in both the mammary epithelium and the mammary mesenchyme, but more prominently within the mesenchme (arrows). Note the absence of expression in the epidermis (E).