Fig. 6. PTCH1 and SMO protein expression in human breast cancer. Representative expression patterns are shown with total immunohistochemical score for the sample, with the proportion and intensity scores in parentheses. PTCH1 is readily detectable in normal breast epithelium and isolated stromal cells (A), but shows a relative loss in the epithelium in DCIS (B) and IBC (C) (P<0.0001). SMO expression is undetectable in normal breast (D), but is detectable in the cytoplasm in 70% of DCIS (E) and 30% of IBC (F) (P<0.0001). (G) Average total IHC scores for SMO and PTCH1 in clinical samples of human breast.