Fig. 7. A novel pathway involving mTOR and Mdm2 signals cell survival. Upon Hgf stimulation, Met triggers the nuclear translocation of Mdm2 by activating the PI3K-Akt pathway. In addition, Met enhances Mdm2 translation by acting on Akt-mTOR via PI3K. The relevance of this mechanism for Met-triggered cell survival has been genetically and pharmacologically demonstrated. Blocking a single step of this pathway alters the cell survival/death balance in embryonic cells.