Fig. 2. A comparison of wild-type and Foxe3 mutant mouse eyes. (A) Hematoxylin-Eosin (HE)-stained coronal section of a P14 wild-type mouse eye showing a lens stained in pink. (B) An HE-stained coronal section of a P1 eye from a dyl mouse showing an abnormal small lens, cornea and retina (blue). (C,D) Coronal sections of eyes from P14 Foxe3^-/- mice showing abnormal features of the lens, cornea and retina. Note the rudimentary lens (arrowed) in D. (E) Cerebral magnetic resonance imaging (MRI) of a 3-year-old human subject with a mutated FOXE3 gene, showing absence of the lens. (F) An HE-stained section through the eye of a 3-month-old child with a mutated FOXE3 gene, showing the absence of the lens (arrow). The asterisk indicates the empty cavity, most likely corresponding to the vitreous. c, cornea; l, lens; on, optic nerve; r, retina. A,C,D are reproduced with permission from Medina-Martinez et al. (Medina-Martinez et al., 2005); B is from I. Brownell and M.J., unpublished; E,F are reproduced with permission from Valleix et al. (Valleix et al., 2006).