Fig. 4. N-Myc deficiency causes syndactyly. (A) Dorsal view of left paws (autopods) of PC and PC-NMyc^f/f mouse limbs at E15.5. Note the syndactyly of the central three digits and protruding digits 1 and 5 of PC-NMyc^f/f limbs. (B) Absence of digit individualization in N-Myc-deficient autopods at postnatal day 1. Autopods were stained for E-cadherin (green, arrow) to mark the epithelium and counterstained with a pan-cytokeratin antibody (red). (C) Dorsal and ventral views of forelimbs and hindlimbs of 1-week-old mice.