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Figure 5


Fig. 5. The relationship between N-Myc expression and programmed cell death in the developing mouse forelimb autopod. (A-R) Whole-mount in situ hybridization of N-Myc is compared with whole-mount staining with LysoTracker, and sections stained for TUNEL at E12.5, 13.5 and 14.5 as indicated. For TUNEL staining at E13.5, higher magnification views of distal regions of digits 4 and 5 of Prx1-Cre (O) and PC-NMycf/f (R) are shown.