Fig. 8. Model of potential integrin and dystroglycan hierarchies. (A) In a sequential model, laminins interact preferentially with integrins in newly formed oligodendrocytes (1) during the regulation of survival and process outgrowth, and preferentially with dystroglycan during the later stages (2), such as myelin membrane formation. (B) In a parallel model, laminins interact with both integrins and dystroglycan to promote myelin membrane formation, but receptor crosstalk or signaling changes can alter the relative contribution of each receptor during distinct oligodendrocyte developmental stages.