Fig. 6. Pn-1-deficient mice express higher levels of cyclin D1 and cyclin D2 in their cerebella. Cerebellum cortices of P10 Pn-1^+/+ and Pn-1^-/- mice were homogenized and processed for immunoblot analysis. After densitometric quantification, the protein levels were monitored relatively to beta-actin and normalized to the Pn-1^+/+ value. Both cyclin D1 (A) and cyclin D2 (B) levels are increased in the mutant cerebellum. Values shown represent mean±s.e.m. ^*P<0.05 (Student's t-test).