Fig. 8. 3-D reconstruction of representative wild-type and Pn-1-deficient adult cerebella. (A-F) Half-cerebella of two representative wild-type (Pn-1^+/+; A,C,E) and Pn-1-deficient mutant (B,D,F) mice are shown as 3-D reconstructions from different angles. (A,B) The cerebella shown as mid-sections. Notice that the overall size of the mutant cerebellum (B) is increased. In particular, lobes V and IX appear extended in the direction of the yellow arrows. (C,D) The cerebella shown from a posterior angle. In the mutant mouse, lobe IX (yellow arrow), again appears enlarged in its mid-part (red double arrows). (E,F) View from the mid-anterior side. The central part of the mutant cerebellum appears clearly enlarged (red double arrows) and lobe IX (yellow arrows) protrudes more than in its wild-type counterpart.