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Figure 4


Fig. 4. Effect of mutations in FP sites on I12b enhancer activity. Lateral views of E11.5 transgenic mouse embryos showing expression of the lacZ reporter in the forebrain. Wild-type (I12b-lacZ) enhancer (A) and enhancers with mutagenized (B,E) DLX/MSX/NKX2.5 sites, (C) MEIS1 site, (D) FP3 homeodomain-binding site, (F) MASH1 site, and (G) FP6 homeodomain site. VT, ventral telencephalon; Di, diencephalon. FN, frontonasal prominence. Scale bar: 1 mm.