Fig. 5. Abnormal development of the Wolffian and Müllerian ducts. Whole-mount immunostaining of urogenital tracts from Dlgh1^+/+ (A-F) and Dlgh1^-/- (G-J) mice at E14.5 (A,B,G), E15.5 (C,D,H) and E16.5 (E,F,I,J) with an anti-Pax2 antibody. (A,C-J) Dorsal view of the urethra and bladder. (B) Diagonally oriented dorsal view of the basal part of the right ureter. The Müllerian ducts do not fuse laterally in Dlgh1^-/- mice and the ureter and Wolffian duct are often connected to the common nephric duct, which is indicated by arrowheads (G,H). bl, urinary bladder; Md, Müllerian duct; sv, primordium for the seminal vesicle; ur, ureter; Wd, Wolffian duct. Scale bars: 200 µm.