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Figure 1


Fig. 1. Enhanced expression of the WNT reporter in the Dkk1-/- embryo. (A-J) Expression pattern of the BATGal reporter in (A-E) wild-type and (F-J) Dkk1-/- embryos (A,F, E7.0; B,G, E7.5; C,H, E7.75; D,I, E8.5; E,J, E9.5). In the mutant embryos, the lacZ expression domain expands to the anterior germ layer tissues at E7.0-7.75, encompasses the whole head folds at E8.5 and reaches the rostral-most region of the truncated head. Scale bar: 50 µm.