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Figure 2


Fig. 2. Knockdown of Xc-Myc provokes edema and compromises organogenesis. (A) Embryos injected with Xc-Myc morpholino (Xc-Myc Mo) at the one-cell stage developed edema in the head and heart region (white arrows). By stage 45 (right panels) massive edema and associated defects in organogenesis were obvious in Xc-Myc knockdown tadpoles (Xc-Myc Mo). (B-D) Histological analysis (stage 37) of Xc-Myc knockdown embryos revealed profound developmental defects: somites (S), spinal cord (SC), notochord (N), abdominal cavity (ac), heart (H), pronephros (PN), dorsal aorta (DA) and cardinal vein (CV). (C) The heart is shown. (D) The region containing the dorsal aorta and cardinal vein.