Fig. 5. Edema provoked by Xc-Myc knockdown is intrinsic and specific and Xc-Myc overexpression induces ectopic vascular beds. (A) The percentage of Xc-Myc morpholino-injected embryos that developed edema (light blue bars) or appeared normal (dark blue bars) is shown. Co-injection of Xc-Myc-Mut rescued the edema phenotype. (B) Representative images of stage 45 control (i) or those injected with Xc-Myc morpholino (ii), with both Xc-Myc-Mut mRNA and Xc-Myc morpholino (iii) [note rescue of phenotype and hypervascularization (black arrows)], or with Xc-Myc RNA (iv), showing hypervascularization and ectopic vascular beds (black arrows). (C) The percentage of Xc-Myc morpholino-injected embryos with hemorrhage. Co-injection of Xc-Myc-Mut mRNA rescued the phenotype. Injection of either wild-type Xc-Myc or mutant Xc-Myc-Mut mRNA induced hypervascularization (red bars).