Fig. 4. Distinct pharmacological properties of EPPs recorded from wild-type and ^-/- muscles. (A) Sample EPP traces recorded from wild-type or ^-/- muscles in normal Ringer's, or in Ringer's with A-conotoxin OIVB (10 µM). (B) Quantification of normalized EPP amplitudes. EPPs in wild-type muscles, but not ^-/- muscles, were sensitive to A-conotoxin OIVB. (C) Sample EPP traces recorded from wild-type or ^-/- muscles in normal Ringer's, or in Ringer's with waglerin 1 (1 µM). (D) Quantification of normalized EPP amplitudes. Bath application of waglerin 1 (1 µM) in Ringer's completely blocked the EPPs in the ^-/- muscles, but was much less effective in the wild-type muscles. ^*P<0.05, ^***P<0.001 (Student's t-test).