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Figure 5


Fig. 5. ISL1 and BRN3B regulate the expression of a common set of RGC-specific genes. (A-H) Compared with controls (left panels), in situ hybridization shows that at E14.5, the expression of RGC-specific genes Brn3a, Isl2, Olf1, Irx4, Ablim1, Gap43, L1cam and Shh decreases in the GCL (bracket) of both Isl1-null (middle panels) and Brn3b-null retinas (right panels). T, temporal; N, nasal. Scale bar: 100 µm.