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Figure 6


Fig. 6. Integrin complexes are maintained at the MTJ. (A,B) MTJs in diaphragm muscle from wild-type and Tln1 mutant mice were analyzed by transmission electron microscopy to reveal the lamina densa. A continuous basement membrane (arrowheads) was present at the MTJ in mutants. (C-N) Localization of collagen IV, laminin, integrin {alpha}7β, vinculin, Ilk and talin 2 at MTJs (arrowheads) was analyzed by immunofluorescence microscopy. All analyzed proteins were present at MTJs in wild-type and mutant animals. t, tendon, m, muscle. Scale bars: 500 nm in A,B; 100 µm in C-F; 200 µm in G-N.