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Figure 5


Fig. 5. Gli3 is not required to establish the mes/r1 roof plate. (A-F) RNA in situ hybridization for Gdf7 and Wnt1 on transverse sections of E9.5 mouse embryos. Gdf7 and Wnt1 are expressed in the roof plate (RP) in the WT and mutant embryos. Note that the Wnt1-positive domain in the lateral mes (*) is in the isthmic region. (G-J) RNA in situ hybridization for Msx1 and Axin2 on E10.5 transverse sections shows that RP expression is not changed in Gli3-/- mutants. (K) Plane of section is indicated in this schematic. The neural tube is outlined where necessary. Scale bars: 100 µm.