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Figure 4


Fig. 4. Mutation of β-catenin after placode initiation blocks hair follicle downgrowth and causes abnormal epidermal stratification and pigmentation. (A-F) H&E-stained sections of E16.5 (A,B) or P1 (C-F) dorsal skin from littermate control and KRT5-rtTA tetO-Cre Ctnnb1(Ex3)fl/+ embryos doxycycline treated from E13.5 (A,B) or E15.5 (C-F). (E,F) Higher magnification views of C,D. Placodes (arrows) are abnormal and expanded at E16.5 (A,B), but hair follicle downgrowth (arrows) fails (C,D). Epidermal stratification is abnormal in the mutants (blue arrows; E,F). (G,H) Precocious pigmentation (arrow) of newborn mutant induced from E15.5. Scale bars: bar in D applies to A-D; in F, to E,F.