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Figure 2


Fig. 2. The canonical Wnt pathway positively regulates components of the Notch pathway in the otic placode. (A) Jag1, Notch1, and Hes1 domains are ectopically expanded in cAct embryos (bracket). Insets show corresponding whole mounts. Arrowheads indicate normal (top row) or ectopic (bottom row) expression; dotted outline demarcates the otic area. (B) Jag1, Notch1 and Hes1 domains are reduced in β-cat-CKO embryos. (Top panels) Anti-Jag1 (red) and β-catenin (β-cat, green) co-immunostaining. Bracket indicates β-catenin-; Jag1- cells. Inset shows Jag1 expression at E9.5 in whole mount. (Lower panels) Sections of Notch1- and Hes1-hybridized embryos. Scale bar: 50 µm.