Fig. 2. Ventral dermal cells originate from the LPM. (A-E) X-gal-stained transverse sections. (A) At E16.5, HoxB6Cre; R26R lineage-marked cells comprise the ventral dermis. (B-E) HoxB6Cre-ER^T1; R26R embryos were given Tamoxifen at E7.5 and β-gal⁺ cells are found in the flank mesenchyme at E11.5 (B, arrows). (C-E) Later at E17.5, β-gal⁺ cells are found in the dermis (small arrows) and dermal papillae (dp) of the hair follicle (hf), and in the sternum and endothelial cells (ec, arrows). Dashed line demarcates the epidermis from the dermis in the embryonic skin. (D,E) High magnification images of the boxed areas in C.