Fig. 3. Blood vessel structure of Lkb1lox/-, Tie1-Cre
conceptuses at E11.5. (A,B) Whole-mount VE-cadherin staining
of wild-type (A) and Lkb1lox/-, Tie1-Cre (B) yolk sacs.
(C,D) Whole-mount PECAM1 staining of wild-type (C) and
Lkb1lox/-, Tie1-Cre (D) yolk sacs. Insets show higher
magnification of single vessels. (E,F) Hematoxylin and
Eosin-stained sagittal sections from wild-type (E) and
Lkb1lox/-, Tie1-Cre (F) embryos. Arrows indicate the
aortas; asterisks, the livers. Arrowhead in F indicates congested blood in the
Lkb1lox/-, Tie1-Cre aorta.