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Figure 4


Fig. 4. Vav-iCre-mediated c-myc deletion results in cytopenia, vascular defects and lethality. (A,B) Live embryos at 11.5 dpc. (C-H) Anti-CD31-stained whole-mount yolk sacs (C,D) and heads (E-H) at 11.5 dpc. CA, internal carotid arteries; HA, primary head veins. Scale bars: 200 µm. (I) Peripheral blood cell counts of control (n=16) and Vav-iCre;c-mycflox/- mutant (n=8) embryos. The numbers above brackets show the fold decrease in the mutants compared with controls. *P<0.01 and **P<0.05 by Student's t-test.