Fig. 8. Homozygous HLEA mice show reduced size of hindlimb bones. (A,B) Bar charts showing mean sizes of wild-type (black bars) and homozygous HLEA mutant (gray bars) bones in hindlimbs (A) and forelimbs (B) of adult mice. Error bars indicate s.e.m. Red brackets in diagrams to right show positions of measurements. (C) Metatarsals and phalanges of digit rays 1 (red), 3 (blue) and 5 (gray) were measured in the feet of the wild type and homozygous mutants. Shown are percent decreases in the sizes of individual bones, or in the combined length of digit rays, in mutants compared with wild type. ^*P<0.05, ^**P<0.005, ^***P<5x10^-5.