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Figure 2


Fig. 2. Neural crest cell migration is initially normal but later disrupted in erbb3b mutants. (A-H) Whole-mount labeling using crestin (A,B,E-H) or sox10 (C,D) riboprobes of wild-type embryos (A,C,E,G) and erbb3b mutants (B,D,F,H). At 24 hpf, both probes show that NC cell migration appears normal in erbb3b mutants (B,D) and in wild type (A,C). At 27 (E,F) and 30 (G,H) hpf, NC cells form segmental streams ventral of the notochord in wild type (E,G). By contrast, in erbb3b mutants (F,H) there are no streams at these stages, and NC cell migration is disrupted. Broken lines represent dorsal aspect of the notochord. Lateral views, anterior towards the left. Scale bar: 20 µm.