Fig. 6. Reduced expression of angiogenic factors in Cx43-deficient uteri. (A) Uterine sections from Cx43^fl/fl mice on day 7 (a) and day 8 (b) and those from Cx43^d/d mice on day 7 (c) and day 8 (d) were subjected to immunohistochemical analysis using anti-Vegf antibody. E, implanted embryo; M, the mesometrial region. (B) qPCR analysis was performed to monitor angiopoetin 2 and angiopoetin 4 mRNA expression in the uteri of Cx43^fl/fl and Cx43^d/d mice on day 8 of pregnancy (n=3).