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Figure 8


Fig. 8. Blocking ROS suppresses synaptic terminal degeneration in SdhA mutant R cells. (A-O) Cross sections of the lamina neuropil (A-J) and retinas (K-O). (A,F,K) 5-day-old wild-type flies grown on food treated with 200 µg/ml {alpha}-tocopherol. (B,G,L) 5-day-old SdhA1110 mutant flies treated with vehicle alone. 5-day-old (C,H,M) SdhA1110 and (D,I,N) SdhA1404 mutants treated with 200 µg/ml {alpha}-tocopherol. (E,J,O) SdhA1110 mutant overexpressing CuZnSOD. Laminas are stained (A-E) for R cells (green) and vesicles (magenta). (F-J) Single channel images stained for vesicles of 5-day laminas. Insets show single synaptic cartridges (A-E) or ommatidia (K-O). Scale bars: 20 µm.