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Figure 2


Fig. 2. Transcriptional misregulation in CTCF-depleted oocytes. (A) Percentages of genes within 0 (overlapping), 5, 10 and 50 kb of a CTCF-binding site. The proportions of nearby upregulated and especially downregulated genes were significantly higher than background (all genes) within every distance threshold. *P<0.05; **P<10-8, {dagger}P<10-7, {ddagger}P<10-5.(B) Percentages of CTCF binding sites within 5 kb of all, upregulated and downregulated genes. Among sites within 5 kb of downregulated genes, the percentage of upstream sites was significantly higher than the percentage of downstream sites, compared with background. *P<0.05.