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Figure 1


Fig. 1. spon-1 mutants are defective in epidermal morphogenesis and muscle attachment. (A) The wild-type L1 larva has a smooth epidermal shape. (B,C) spon-1(e2623) L1 larvae and adults display variable defects in epidermal morphology. The bent body phenotype is more obvious during early larval stages (B), whereas some adults display `pinched' head morphology (arrow, C); other e2623 phenotypes include egg laying defects and a slightly shorter body length. (D) A wild-type embryo at 3-fold stage. (E) spon-1(ju402) mutant embryo, displaying elongation arrest and uneven epidermal morphology (arrow). (F) spon-1(ju430) mutant hatchling showing elongation arrest with lumpy 2-fold morphology and detached body wall muscles (arrow). Scale bar: 10 µm.