Fig. 10. hnRNP K suppression disrupts cytoskeletal cytoarchitecture. (A,C,E) Bilaterally injected control MO cultures exhibited normal distributions for all three cytoskeletal elements (A, phalloidin-stained F-actin; C, peripherin-immunostained neurofilaments; E, neuron-specific β-tubulin). (B,D,F) The cytoarchitectures of these elements was significantly disrupted in bilaterally injected hnRNP K MO cultures. F-actin circumscribed the cell body and was concentrated towards one side (B). Peripherin formed twisted filaments and aggregates (D), and neuronal β-tubulin formed ring-shaped structures (F).