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Figure 6


Fig. 6. Cellular hierarchy of cardiac progenitors and their lineage specification. The expression of the lineage markers shown is based on previous studies (Kattman et al., 2006; Moretti et al., 2006; Wu et al., 2006). The divergence of endothelial and haematopoietic lineages from the myocardial lineage precedes the expression of Nkx2-5 in the precardiac mesoderm (tissue-specific markers are shown in blue). Bry, brachyury (T); MLC2a, atrial myosin light chain 2 (also known as Myl7); MLC2v, ventricular myosin light chain 2 (Myl2); cTnT, cardiac troponin T (Tnnt2); Hcn4, hyperpolarization-activated cyclic nucleotide-gated K+ 4; sm-actin, smooth muscle actin; SM-MHC, smooth muscle myosin heavy chain; VE-Cadh, VE-cadherin.